The development and physicochemical characterization of solid lipid nanoparticles (SLNs)\nwith potential for formulating hair cosmetic products were carried out. SLNs were made from\nOtoba wax, which is native to the tropical Andean region and has a high chemical composition of\nfatty acids with intermediate chains. SLNs were formulated by preparing wax-in-water dispersions\nat two internal phase proportions (low = 5% w/w and high = 20% w/w), using the same ratio of\nsurfactant system and preservatives. The coarse dispersions were subjected to ultrahigh pressure\nhomogenization (UHPH), and thermal stability assays for 4 weeks were carried out, where changes\nin Creaming Index, droplet size, polydispersity, viscosity, zeta potential, conductivity, and pH were\nevaluated. The results showed that Otoba wax has a required HLB value around 9 and is mainly\ncomposed of lauric (~35%) and myristic (~45%), which have been reported to improve the condition\nof hair loss. Regarding the development on SLNs, it was found that the internal phase concentration\ndid not considerably affect the physicochemical and microbiological properties. Likewise, it was\nfound that UHPH enabled the production of SLNs with particle sizes <200 nm, low polydispersity\n(<0.3), high zeta potential values, and suitable physical and microbiological stability. Therefore,\nOtoba wax has potential for the development of SLNs applicable to cosmetic formulations, especially\nfor hair products.
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